It has been widely reported and confirmed publicly that, on August 29, the U.S. Department of Health and Human Services (HHS) sent a letter to the Drug Enforcement Administration (DEA) recommending that cannabis be moved from Schedule I to Schedule III of the Controlled Substances Act (CSA). While this change would not lift the federal prohibition on cannabis, and the DEA will need to perform its own review, the move could have profound implications for researchers and industry participants.

Currently, cannabis is classified under Schedule I of the CSA, a category reserved for substances with a high potential for abuse, no accepted medical use in treatment in the U.S., and a lack of accepted safety for use under medical supervision. This classification imposes significant barriers to research and substantial tax burdens on state-legal cannabis businesses. The HHS recommendation, reportedly based on a review by the Food and Drug Administration (FDA), proposes moving cannabis to Schedule III, a category for substances with a lower potential for abuse, accepted medical use in treatment in the U.S., and moderate to low physical dependence or high psychological dependence. Examples of Schedule III-controlled substances listed on the DEA’s website include products containing not more than 90 milligrams of codeine per dosage unit (e.g., Tylenol with Codeine®), buprenorphine (Suboxone®), ketamine, and anabolic steroids such as Depo®-Testosterone.

Why It Matters

It is important to note that a move to Schedule III will not convert cannabis products into consumer-packaged goods that can be purchased over the counter at convenience stores, gas stations, or grocery stores — a prescription would be required. The move would also not help to clarify the status of state-legal recreational cannabis systems, as Schedule III substances may not be sold or used recreationally under federal law. The rescheduling of cannabis to Schedule III would, however, have significant legal implications for researchers and industry participants.

Retail cannabis businesses would be able to deduct ordinary business expenses from their federal income taxes, a benefit currently unavailable due to Internal Revenue Code Section 280E, which forbids businesses from deducting otherwise ordinary business expenses from gross income associated with the “trafficking” of Schedule I or II substances. While some states have taken measures to ease the tax burdens on retail cannabis businesses at the state level, this change at the federal level could dramatically improve the financial viability of retail cannabis businesses, some of whom currently pay upwards of 70% in income taxes. Cultivators and manufacturers are not subject to the same restrictions under 280E, so a move to Schedule III may not provide much relief to those portions of the industry.

Moreover, the rescheduling of cannabis to Schedule III could also ease restrictions to access for cannabis researchers. The Schedule I classification imposes significant requirements on researchers, making it difficult for scientists to study the potential benefits and risks of cannabis. The move to Schedule III could unlock new opportunities for research, potentially leading to new medical treatments and a better understanding of cannabinoids like tetrahydrocannabinol, the main psychoactive substance contained in cannabis plants.

The HHS’s recommendation to move cannabis to Schedule III of the CSA could have far-reaching implications for the cannabis industry and research community. While it’s still early days, and action from the DEA will be required, the potential changes could significantly impact the legal and regulatory landscape for the cannabis industry in the U.S. Based on prior precedent, moving cannabis to Schedule III would require administrative rulemaking and opportunity for comment, which could take anywhere from 18 months to several years for DEA to complete.


Our Cannabis Practice provides advice on issues related to applicable federal and state law. Marijuana remains an illegal controlled substance under federal law.

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Photo of Agustin Rodriguez Agustin Rodriguez

Agustin is sought after by clients for his strategic counsel on their most challenging competitive and regulatory compliance issues, including tobacco Master Settlement Agreement issues, federal and state enforcement investigations, licensing and excise tax issues, developing compliance programs, and evaluating advertising and marketing…

Agustin is sought after by clients for his strategic counsel on their most challenging competitive and regulatory compliance issues, including tobacco Master Settlement Agreement issues, federal and state enforcement investigations, licensing and excise tax issues, developing compliance programs, and evaluating advertising and marketing practices. A partner in the firm’s Regulatory Investigations, Strategy + Enforcement (RISE) Practice Group as well as its Tobacco and Cannabis law practices, he represents manufacturers, distributors, retailers, and suppliers in all aspects of their businesses, including regulatory compliance, FDA requirements, administrative disputes involving federal or state governmental entities, mergers and acquisitions, commercial agreements, and taxation matters.

Photo of Jean Smith-Gonnell Jean Smith-Gonnell

Jean has dedicated her entire career to the cannabis sector, helping growers, dispensaries, investors, receivers, and other stakeholders achieve their business goals and prepare for unexpected issues. She has extensive experience with medical marijuana, retail marijuana, hemp, and CBD products, and helps clients…

Jean has dedicated her entire career to the cannabis sector, helping growers, dispensaries, investors, receivers, and other stakeholders achieve their business goals and prepare for unexpected issues. She has extensive experience with medical marijuana, retail marijuana, hemp, and CBD products, and helps clients as they establish their businesses, mitigate risk, and resolve disputes. Known for responding to clients within 24 hours or less, Jean is also a go-to advisor for a wide range of day-to-day operational issues.

Photo of Cole White Cole White

Cole is a member of the firm’s Regulatory Investigations, Strategy and Enforcement (RISE) group. He has a decade of experience working in the attorney general community, having joined the firm from the Wyoming Office of the Attorney General, where he was assistant attorney…

Cole is a member of the firm’s Regulatory Investigations, Strategy and Enforcement (RISE) group. He has a decade of experience working in the attorney general community, having joined the firm from the Wyoming Office of the Attorney General, where he was assistant attorney general.